Molecular docking activity of peristrophe bivalvis on non small cell lung cancer

Cancer is a genetic disease in which cells are unable to control their functions normally. As cancer develops, old will survive when they should die, and new grow not needed. These extra can divide endlessly form growths called tumors . This research was carried out know whether peristrophine, apioside, pelargonidin 3-Sambubioside compounds could be developed as drug Non-Small Cell Lung (NSCLC) with the silico method at ROS1 receptor Protein Data Bank code 3ZBF native ligand crizotinib. Peristrophine, have an affinity for protein binding energies of -6.12 kcal/mol on -6.74 -7.54 3-Sambubioside. molecular mechanism inhibiting through formation hydrogen bonds ROS1. From Lipinski's analysis, peristrophine test compound has met requirements seen from LD50 value compound, apioside same toxicity class comparison namely crizotinib 4 toxicity.